29th Annual North American Cystic Fibrosis Conference

Oct 7, 2015 ‐ Oct 10, 2015



The synchronized sessions from the 2015 NACFC are NOW AVAILABLE!

Full NACFC registrants have complimentary access to the recordings of the 2015 NACFC Plenary sessions, Symposia and Workshops.

Short Course presentations held on Wednesday, October 7, are also available for an additional fee. To purchase access to the Short Course presentations, click here.


Sessions

S03: INF/MIC: Challenging Topics in Infectious Disease

Oct 8, 2015 2:00pm ‐ Oct 8, 2015 3:50pm

This session will focus on challenging topics in infectious diseases management of CF including the role of viruses & the impact of newer diagnostic testing, Clostridium difficile infections & how they impact CF patients, nontuberculous mycobacterial infections in CF & the eradication of Pseudomonas aeruginosa both in younger children as well as in adults.

Educational Objectives:

  1. Describe the role of viruses and newer diagnostic testing in patients with CF.
  2. Discuss the impact of atypical infections such as Clostridium difficile & nontuberculous mycobacterial infections in CF.
  3. Examine the different eradication strategies for Pseudomonas aeruginosa infection in children & adults with CF.

Speaker(s):
Standard: $49.99

S04: CLIN: CFTR & PancreatitisS04: CLIN: CFTR & Pancreatitis

Preview Available

S04: CLIN: CFTR & Pancreatitis

Oct 8, 2015 2:00pm ‐ Oct 8, 2015 3:50pm

This session will focus on the role of CFTR in normal exocrine pancreatic function & how defects predispose to pancreatitis. The link between specific CFTR mutations & risk for pancreatitis & exocrine pancreatic insufficiency will be discussed. Lastly, the impact of CFTR on beta cell function & the factors that predispose to CF-related diabetes mellitus will be reviewed.

Educational Objectives:

  1. Define the role of CFTR in normal exocrine pancreatic function & how defects lead to pancreatitis.
  2. Identify how specific CFTR mutations predict the risk of pancreatitis & the implications for specific therapies.
  3. Describe the impact of loss of normal CFTR function on beta cell function & its clinical implications.

Speaker(s):
Standard: $49.99

S05: CLIN: Toward Rational Management of Pulmonary Exacerbations: Part III

Oct 8, 2015 2:00pm ‐ Oct 8, 2015 3:50pm

Pulmonary exacerbations are common events in patients with CF but there is no standard approach to treatment. We will review what we have learned from registry data, clinical studies & an observational study of exacerbations & how this will be used in the design of interventional studies of the treatment of exacerbations.

Educational Objectives:

  1. Review the epidemiology of CF pulmonary exacerbations and their management.
  2. Discuss the topline results from an observational study of pulmonary exacerbations.
  3. Define the relevant clinical endpoints for the design of interventional studies of pulmonary exacerbations.

Speaker(s):
Standard: $49.99

S07: PT & RT: Non-pharmacological Treatment of Pain in CF: A Musculoskeletal Approach

Oct 8, 2015 2:00pm ‐ Oct 8, 2015 3:50pm

Chronic pain is a common issue in individuals with CF. When identified, health care providers routinely prescribe pharmacological agents to reduce the burden of pain. This session will discuss the current state of pain issues and delve into non-pharmacological interventions, such as physical medicine and behavioral modification, useful in pain management strategies for individuals with CF.

Educational Objectives:

  1. Review the qualitative descriptors of pain in CF.
  2. Recall the complementary and non-pharmacologic modalities for pain.
  3. Describe practical techniques in behavioral and physical therapy, such as: hypnosis, behavior modification and thoracic release, and identify how these learned techniques can be implemented with minimal effort or resources.

Speaker(s):
Standard: $49.99

*** S06: NRS: Partnering With Patients & Families to Promote Healthy Lifestyles

Oct 8, 2015 2:00pm ‐ Oct 8, 2015 3:50pm

This symposium will focus on a holistic approach to wellness strategies for patients & families through dietary, physical, emotional & lifestyle interventions. The presentations will encompass coping strategies & stress reduction, a new spin on healthy dietary considerations, evidence-based complementary healing modalities & practical exercises & their impact on patients' health.

Educational Objectives: 

  1. Describe potential coping strategies & alternative therapies that promote health & wellness.  
  2. Discuss three dietary considerations to promote a healthy lifestyle for individuals with CF & their families.
  3. List recommended exercises for individuals with CF to promote their physical well-being.
*** This session was streamed live during the 2015 NACFC. To watch free archived versions of the live streamed sessions, register here: https://arc.nacfconference.org/cff/live/14 

Speaker(s):
Standard: $49.99

*** P1: Personalized Medicine*** P1: Personalized Medicine

Preview Available

*** P1: Personalized Medicine

Oct 8, 2015 4:20pm ‐ Oct 8, 2015 6:00pm

This session will discuss the concept of personalized medicine in CF, including how therapies are currently personalized & how new medications & tools will allow us to personalize therapy in a precise way.

Educational Objectives:

  1. Define the role of CFTR-targeted therapies in personalization of CF care.
  2. Describe how patient-derived model systems may facilitate the evaluation of new therapies on a patient-specific basis.
  3. Evaluation the role of emerging monitoring tools to track new CF patient interventions.
*** This session was streamed live during the 2015 NACFC. To watch free archived versions of the live streamed sessions, register here: https://arc.nacfconference.org/cff/live/14 

Speaker(s):
Standard: $49.99

*** P2: Opening Doors to CF Clinical Research

Oct 9, 2015 9:00am ‐ Oct 9, 2015 10:00am

This session will review highlights of clinical research from the past year & look forward to the large number of new studies ahead. The increased number of studies & potential new therapies will allow even more patients & centers to get engaged in clinical research. New approaches & tools will be needed to accomplish this work. This session will address the role centers will play going forward.

Educational Objectives:

  1. Describe & summarize key results for recent trials in CF & explain their significance within the therapeutic class.
  2. Review the upcoming trials across each therapeutic area & illustrate the increased need for patient & center participation to meet the goals of better therapies.
  3. Demonstrate the importance of research in improving outcomes & explain how to access research information.
*** This session was streamed live during the 2015 NACFC. To watch free archived versions of the live streamed sessions, register here: https://arc.nacfconference.org/cff/live/14 

Speaker(s):
Standard: $49.99

S08: CFTR: It's in Your Genes: Understanding CFTR Gene Regulation to Improve CF Treatment

Oct 9, 2015 10:30am ‐ Oct 9, 2015 12:20pm

Mechanisms of regulation of expression of the CFTR gene are complex & involve aspects of chromatin structure, transcriptional & post-transcriptional control. Substantial recent progress in investigating these mechanisms opens the possibility of manipulating gene expression for therapeutic benefit. Specifically increasing CFTR mRNA abundance could provide more substrate for corrector drugs.

Educational Objectives:

  1. Obtain a general understanding of gene expression mechanisms.
  2. Discuss how the CFTR gene is regulated in differentiated cell types.
  3. Describe novel methods to find regulatory elements.
*Ann Harris' presentation is not available for viewing at the speaker’s request.

Speaker(s):
Standard: $49.99

S09: CFTR-NT: Developing Co-therapies to Modulate CFTR

Oct 9, 2015 10:30am ‐ Oct 9, 2015 12:20pm

This session will highlight the issues around co-therapies from the clinical to the development.

Educational Objectives:

  1. Discuss the need for co-therapies in CF for different combinations of CFTR mutations & the benefits & disadvantages of co-therapies.
  2. Analyze how to screen for additive/synergistic drugs.
  3. Demonstrate how to assess benefit of CF co-therapies.

Speaker(s):
Standard: $49.99

S10: NT: Assessing Presymptomatic Children

Oct 9, 2015 10:30am ‐ Oct 9, 2015 12:20pm

CF lung disease often begins before the onset of overt clinical symptoms. Objective monitoring of disease progression is challenging, particularly in young children. This symposium will highlight advances in lung function, imaging, metabolomics & biomarkers aimed at detecting early changes in the CF lung.

Educational Objectives:

  1. Review the need for improved, sensitive measures of lung disease in presymptomatic children with CF.
  2. Assess the role of chest imaging & lung clearance index in detection of lung disease in presymptomatic children.
  3. Evaluate the utility of biomarkers in monitoring disease progression in presymptomatic children.

Speaker(s):
Standard: $49.99
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