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32nd Annual North American Cystic Fibrosis Conference

S22--NT-APP&D: Resolution of Inflammation in CF Airways: CFTR & Beyond

Oct 20, 2018 2:30pm ‐ Oct 20, 2018 3:55pm


Airway disease remains the leading cause of morbidity and mortality in individuals with cystic fibrosis. The absence of CFTR leads to multiple changes in airways surface secretions and host defenses that are associated with severe and sustained airway inflammation. Correction of CFTR function may decrease part of the inflammatory process and prevent tissue destruction. However inflammation independent of CFTR is likely to persist. This symposium will address both CFTR -dependent and -independent mechanisms of resolving inflammation.

Learning Objectives:

  • Describe the impact of CFTR modulators on the host inflammatory response in cystic fibrosis.
  • Define the roles of macrophages and pro-resolving mediators in the CF airway inflammatory response.
  • Describe the results of a recently completed clinical trial of an anti-inflammatory drug in cystic fibrosis.

Symposium Chair(s):

Symposium Speaker(s):

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