This workshop will initially discuss how insights into mechanisms regulating CFTR biosynthesis can help identify new targets for therapeutic intervention. A new tool for detecting plasma membrane CFTR, which could be used in high-throughput setting, will be also presented. The section will end with discussing how the newly resolved cryo-EM CFTR structures may enable structure-based drug design.
Define folding and misfolding of CFTR.
Describe how the CFTR biosynthetic pathway can be targeted to correct several CFTR mutation classes.
Evaluate new approaches for assessing CFTR plasma membrane abundance and helping to design new CFTR modulators.
Note: Speaker Yunjie Huang's presentation was not recorded at his request.