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32nd Annual North American Cystic Fibrosis Conference

W02--CFTR: CFTR 2018

Oct 18, 2018 9:45am ‐ Oct 18, 2018 11:05am


Description

This workshop will initially discuss how insights into mechanisms regulating CFTR biosynthesis can help identify new targets for therapeutic intervention. A new tool for detecting plasma membrane CFTR, which could be used in high-throughput setting, will be also presented. The section will end with discussing how the newly resolved cryo-EM CFTR structures may enable structure-based drug design.

Learning Objectives:

  • Define folding and misfolding of CFTR.
  • Describe how the CFTR biosynthetic pathway can be targeted to correct several CFTR mutation classes.
  • Evaluate new approaches for assessing CFTR plasma membrane abundance and helping to design new CFTR modulators.

Note: Speaker Yunjie Huang's presentation was not recorded at his request. 

Workshop Chair(s):

Workshop Speaker(s):

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