It has become increasingly clear that polymicrobial interactions, environmental conditions and evolutionary adaptations are critical to the progression of CF disease. Yet, a lack of ecological perspective has limited the translation of bench research into effective therapeutic strategies. For example, Pseudomonas does not colonize the airways alone - how do other community members and the infection environment impact Pseudomonas physiology? Recently, culture-independent approaches (genomics, transcriptomics and metabolomic) have shed light on CF infection communities, though many outstanding questions remain. In this workshop we will explore the ecology of CF airway infection communities, with the ultimate goal of devising more effective clinical therapies. Talks from scientists studying clinical samples and also recreating polymicrobial communities in the lab will educate the audience about new tools and hypotheses for relating the CF infection ecosystem to disease progression.
Compare and contrast the presented approaches for studying polymicrobial communities in the CF airways that will help us identify evolutionary and ecological instabilities.
Identify missing datasets that are critical for managing CF as an ecosystem.
Exchange information about polymicrobial infection ecology amongst microbiologists, clinicians, and bioinformaticians.