28th Annual North American Cystic Fibrosis Conference

S01: CFTR: Potentiator Action: Not an Open & Shut Case

Oct 9, 2014 2:00pm ‐ Oct 9, 2014 3:50pm

Standard: $49.99

Description

This session will review our understanding of potentiator mechanism of action and compare the effects that potentiators, such as ivacaftor (VX-770), have on different mutant CFTR proteins. Conclusions that allow for determination of candidates for current potentiator therapies will be drawn. Differences in mutant and wild-type CFTR thermal sensitivity will be discussed. Finally, the impact of potentiators on CFTR correction will be addressed.

Speaker(s):

You must be logged in and own this session in order to post comments.