Description

This session will focus on the mechanistic basis for the development of novel, non-CFTR directed small molecule therapies that may improve mucociliary clearance in CF.

Learning Objectives:

• Discuss the mechanistic basis of non-CFTR-mediated anion (Chloride and Bicarbonate) transport in the CF airway, and how small molecules directed at alternate anion transporters may bypass mutant CFTR in the CF airway.
• Discuss the mechanistic basis of hypothesized defects in sodium transport in the CF airway, and how targeting this defect with small molecules may improve the pathophysiology of the CF airway.
• Discuss the mechanistic basis of distorted mucociliary clearance in the CF airway in the context of how utilization of osmotic and mucolytic interventions may lead to improvements.

Symposium Chair(s):

• Ronald Rubenstein, M.D., Ph.D., Director CF Center, Associate Professor
• Scott Donaldson, M.D., Professor

Symposium Speaker(s):

• John W. Hanrahan, B.Sc.,Ph.D., Professor, McGill University
• Camille Ehre, Ph.D., Assistant Professor
• Henry Danahay, Ph.D., Head of Biology