Description
This session will focus on the mechanistic basis for the development of novel, non-CFTR directed small molecule therapies that may improve mucociliary clearance in CF.
Learning Objectives:
- Discuss the mechanistic basis of non-CFTR-mediated anion (Chloride and Bicarbonate) transport in the CF airway, and how small molecules directed at alternate anion transporters may bypass mutant CFTR in the CF airway.
- Discuss the mechanistic basis of hypothesized defects in sodium transport in the CF airway, and how targeting this defect with small molecules may improve the pathophysiology of the CF airway.
- Discuss the mechanistic basis of distorted mucociliary clearance in the CF airway in the context of how utilization of osmotic and mucolytic interventions may lead to improvements.
Note: Speaker Ronald Rubenstein's presentation was not recorded at his request.
Symposium Chair(s):
Symposium Speaker(s):