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28th Annual North American Cystic Fibrosis Conference

S02: APP&D: Airway Innate Defense & CFTR

Oct 9, 2014 2:00pm ‐ Oct 9, 2014 3:50pm

Standard: $49.99


This session focuses on mucosal defense in the airways and its regulation by epithelium-derived factors. Presenters will discuss the following: how airway mucins and airway surface liquid contribute to the maintenance of barrier and immune defenses, the physiological mechanisms that control their homeostatic functions, and the pathophysiological consequences of their dysfunction in CF.

Learning Objectives:
  • Define critical mucin glycoproteins and their functions in innate airway defense.
  • Discuss the mechanisms that control CFTR trafficking and function and the homeostatic mechanisms that control airway hydration status.
  • Describe the effects of dysfunctional mucin secretion and airway hydration on airway obstruction and infection in CF.


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