Recent studies show persistent airway inflammation is an unresolved issue in cystic fibrosis despite long-term use of CFTR modulator therapies. Inflammation is a complex necessary feature of CF lung pathophysiology with a wide variety of contributing factors, and a spectrum of disease response in airway epithelial and immune cells. This session will present current research in CF inflammation in both airway epithelia and immune cells, using in vitro and in vivo model systems. Novel aspects of the complex relationship between CF airway inflammation, mucus production, and airway surface liquid pH will be described, as well as characterization of neutrophil extracellular traps in CF. Research elucidating the role of metabolic pathways in inflammation, and novel targets for anti-inflammatory treatments will be further described. This session will review key pathophysiologic mechanisms contributing to CF lung inflammation, and inform therapeutic strategies to optimize the CF host response.
Describe physiologic effects of inflammatory stimuli on airway surface liquid and mucus secretion characteristics.
Review the characterization and pathophysiologic effects of neutrophil extracellular traps in CF.
Identify metabolic pathways and novel anti-inflammatory therapeutic targets implicated in cystic fibrosis lung disease.
Assistant Professor of Medicine,
University Of Kansas