This session will focus on the most recent advances in the development and use of cellular models for investigating the human Cystic Fibrosis airway epithelium. The session will include talks on both two- and three-dimensional cultures that better recapitulate the native airway epithelium with focus on the application of gene editing, gene delivery, pluripotent stem cells and primary cellular models.
Describe the most recent updates in how cellular model systems can be used to understand the pathogenesis of human CF.
Define the application of gene editing technologies to better modeling human CF.
Discuss the advances in using two and three dimensional models in evaluating CF pathogenesis and therapeutic approaches.