Respiratory infections complicated by ineffective immune responses are hallmarks of Cystic Fibrosis lung disease. In this workshop, we will discuss the early adaptations of bacterial populations in CF to adapt to the host environment. Also highlighted will be mechanisms by which the host environment in CF permits polymicrobial infections, which contribute to lung disease progression. The session will culminate with presentations examining the impact of modulator therapy on host defense in the CF respiratory tract.
Define mechanisms of bacterial evasion of innate immune cells in the early stages of CF infections.
Examine the contribution of viral-bacterial co-infections to lung disease in CF.
Discuss the impact of modulator therapy on innate defenses in the CF lung.