To inform the development of innovative new therapies for CF lung disease, this workshop has three objectives. First, to assess the expression and function of CFTR in different populations of airway epithelial cells, including pulmonary ionocytes, rare cells that highly express the Cftr gene. Second, to appraise the role of CFTR-independent pathways for anion transport in mucociliary clearance, including SLC26A9. Third to discuss the organisation of mucus in bundles in normal airways and sheets in CF airways.
Evaluate the expression and function of CFTR in different types of airway epithelial cells.
Assess CFTR-independent mechanisms of mucociliary clearance.
Review the organisation of mucus in normal and cystic fibrosis airways.
Note: Speaker Pamela Millar-Büchner's presentation was not recorded at her request.