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33rd Annual North American Cystic Fibrosis Conference


W21 - W21--APP&D-CFTR: Airway Ions, Fluids & Mucus Transport


Nov 2, 2019 10:30am ‐ Nov 2, 2019 11:50am

Description

To inform the development of innovative new therapies for CF lung disease, this workshop has three objectives. First, to assess the expression and function of CFTR in different populations of airway epithelial cells, including pulmonary ionocytes, rare cells that highly express the [i]Cftr[/i] gene. Second, to appraise the role of CFTR-independent pathways for anion transport in mucociliary clearance, including SLC26A9. Third to discuss the organisation of mucus in bundles in normal airways and sheets in CF airways.

Learning Objectives:

  • Evaluate the expression and function of CFTR in different types of airway epithelial cells.
  •  Assess CFTR-independent mechanisms of mucociliary clearance.
  • Review the organisation of mucus in normal and cystic fibrosis airways.

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