This session aims to educate attendees on several important clinical topics that can face people with CF. The first talk covers the diagnosis, prevention and management of venous thromboembolism in CF, as well as the potential difficulties of anticoagulant treatment. The second talk discusses strategies to identify, prevent and manage acute kidney injury, chronic kidney disease and hearing loss in CF. The third talk addresses the challenging area of antibiotic allergy and desensitization in CF. The fourth talk covers the scenario where people with CF develop non-CF disease and the difficulties that can arise when the treatment for one condition impacts on the other.