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28th Annual North American Cystic Fibrosis Conference

S15: APP&D: CF Airway Inflammation & Therapeutic Targets

Oct 11, 2014 10:30am ‐ Oct 11, 2014 12:20pm

Standard: $49.99


This symposium begins with an update on the inflammatory response in the CF lung. Airway epithelial and immune cells contribute to inflammation in CF. There is a large influx of neutrophils that release damaging mediators including proteases and oxygen radicals. The second talk focuses on the importance of cellular immunity in CF respiratory pathophysiology, which has only recently begun to be understood. It is well known that nitric oxide (NO) is decreased in CF exhaled gas. The significance of this and the use of NO as a therapy is discussed in the third talk. The final talk reviews the role of anti-inflammatory therapy in CF and provides an update on clinical trials in this area.

Learning Objectives:
  • Define the cellular processes involved in the CF airways inflammation
  • Analyze the methods used to measure CF airway inflammation and summarize current anti-inflammatory therapy
  • Define the role of NO in CF lung disease and understand its therapeutic potential


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