This symposium begins with an update on the inflammatory response in the CF lung. Airway epithelial and immune cells contribute to inflammation in CF. There is a large influx of neutrophils that release damaging mediators including proteases and oxygen radicals. The second talk focuses on the importance of cellular immunity in CF respiratory pathophysiology, which has only recently begun to be understood. It is well known that nitric oxide (NO) is decreased in CF exhaled gas. The significance of this and the use of NO as a therapy is discussed in the third talk. The final talk reviews the role of anti-inflammatory therapy in CF and provides an update on clinical trials in this area.
Define the cellular processes involved in the CF airways inflammation
Analyze the methods used to measure CF airway inflammation and summarize current anti-inflammatory therapy
Define the role of NO in CF lung disease and understand its therapeutic potential
Children's Hospital of Pittsburgh