It is known that anxiety and depression is prevalent throughout the world, with a higher incidence in those individuals with a chronic illness. Currently, an international committee is working to develop Anxiety and Depression Guidelines for all care teams to utilize.Part of the guidelines will be recommendations for treatment which will include Cognitive Behavioral Therapy (CBT). CBT is a known therapeutic intervention that has been successfully used to treat anxiety and depression in a variety of settings. Basic principles of CBT, such as exposure, behavioral activation, or cognitive restructuring will be demonstrated. Modifications of CBT for application with patients with a progressive medical disease will be discussed. This session is intended to assist all members of the interdisciplinary Cystic Fibrosis Care Team to effectively understand and use CBT in the CF Center settings to assist/treat individuals with CF and/or their caregivers. The course is open for all professions involved in the CF team who might be interested to counsel patients and caregivers about opportunities of CBT and to refer patients with CF and comorbid anxiety or depression to adequate treatments.