29th Annual North American Cystic Fibrosis Conference

W02: APP&D-GMS: New Advances in CF Animal Models

Oct 8, 2015 10:00am ‐ Oct 8, 2015 11:45am

Standard: $49.99

Description

This workshop will introduce two rodent models of CF (ΔF508 CFTR rat & a CF mouse expressing human CFTR) & provide new insights into biliary & respiratory CF disease from experiments performed using CF mouse, ferret or pig models. Particular emphasis will be given to evidence demonstrating infection- & inflammation-independent defects in CF airway function.

Educational Objectives:

  1. Summarize the advantages/disadvantages of new CF rodent models (the ΔF508 CFTR rat & human CFTR expressing mouse).
  2. Explain implications of defective biliary ATP release in CF mice & age-dependent defects in CF ferret alveolar macrophages.
  3. Summarize implications of sterile bronchiectasis in CF ferret lungs & inflammation-independent smooth muscle dysfunction in CF pig airways.

Speaker(s):

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