Description

This workshop will introduce two rodent models of CF (ΔF508 CFTR rat & a CF mouse expressing human CFTR) & provide new insights into biliary & respiratory CF disease from experiments performed using CF mouse, ferret or pig models. Particular emphasis will be given to evidence demonstrating infection- & inflammation-independent defects in CF airway function.

Educational Objectives:

1. Summarize the advantages/disadvantages of new CF rodent models (the ΔF508 CFTR rat & human CFTR expressing mouse).
2. Explain implications of defective biliary ATP release in CF mice & age-dependent defects in CF ferret alveolar macrophages.
3. Summarize implications of sterile bronchiectasis in CF ferret lungs & inflammation-independent smooth muscle dysfunction in CF pig airways.

Speaker(s):

• Michel Bagnat, Ph.D.
• Lane L. Clarke, D.V.M.,Ph.D., University of Missouri