Observations in respiratory microbiology are presented, including factors associated with Burkholderia spp. eradication & NTM acquisition. Emphasis on P. aeruginosa (Pa) will include trends in aztreonam susceptibility, response to combined tobramycin & azithromycin & analyses describing stages of infection with mucoid Pa. Ivacaftor's effect on the microbiome in 'Celtic' G551D is presented.
Describe current trends in P. aeruginosa infection in CF & variable response to common therapeutics including antibiotics & CFTR modulators.
Explain environmental risk factors for non-tuberculosis mycobacteria & potentially successful eradication regimens for Burkholderia.
Use observations of the complex respiratory microbiome to improve CF care.