Mechanisms of regulation of expression of the CFTR gene are complex & involve aspects of chromatin structure, transcriptional & post-transcriptional control. Substantial recent progress in investigating these mechanisms opens the possibility of manipulating gene expression for therapeutic benefit. Specifically increasing CFTR mRNA abundance could provide more substrate for corrector drugs.
Obtain a general understanding of gene expression mechanisms.
Discuss how the CFTR gene is regulated in differentiated cell types.
Describe novel methods to find regulatory elements.
*Ann Harris' presentation is not available for viewing at the speaker’s request.