CF airways are dehydrated due to lack of chloride & bicarbonate secretion into the lumen; modulation of CFTR activity can alter ion concentration on the airway surface. In addition to CFTR, there are other potential channel targets for modulation of ion secretion by the epithelium. This session will cover several of these other ion channels & how their activity may be modulated.
Explain why non-CFTR ion channels represent a potential target for CF therapy.
Describe how inhibition of ENaC can be achieved at the molecular level.
Compare the molecular composition & functions of different non-CFTR epithelial anion channels.