This session will highlight the recent and important advances in understanding the mechanisms underlying altered mucus clearance in the CF airway. These talks will focus on three aspects of mucus clearance; fluid secretion, ion transport, and mucus properties and composition. Additionally, the information presented will focus on inter-relationships between these facets of the mucus clearance apparatus.
Explain how modulation of cellular ion transport alters airway surface fluid properties.
Describe how mucins and mucus are altered in CF and contribute to its pathophysiology.
Discuss how changes in airway ion transport, fluid homeostasis, and mucin biosynthesis combine to affect the clearance of mucus.