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28th Annual North American Cystic Fibrosis Conference

W03: GMS: Cell, Organoid & Animal Models

Oct 9, 2014 10:00am ‐ Oct 9, 2014 11:45am

Standard: $49.99


This workshop will focus on emerging research models for investigating the pathogenesis and treatment of cystic fibrosis. In addition to new animal models including the CF rat and ferret, cellular models to be presented range from cell lines expressing multiple CFTR mutations to primary culture methods expanding human airway tissue, generating organotypic structures and investigating male reproductive tract biology. Emphasis is placed on the advantages these research methods offer for investigating the multiple manifestations of CF disease.

Learning Objectives:
  • Define new methods to expand and differentiate affected CF patient tissues in vitro for the investigation of CF pathogenesis and therapeutics.
  • Explain how cell lines expressing CFTR with multiple mutations can be used for the design of new correctors and potentiators of CFTR.
  • Discuss the contribution of CF ferret and rat models to our understanding of CF airway disease including inflammation and embryological development of the male reproductive tract


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