Mandatory newborn screening (NBS) for CF in the US and in other countries has brought attention to new challenges and considerations for healthcare providers. Education and coordination of care with primary providers for testing is just one of many issues that have been experienced by CF care centers. This workshop will explore the way one center addressed this issue. This workshop will also look at how caregivers have responded to carrier status identification; parental understanding of NBS and their psycho-educational needs. The potential for postpartum depression following NBS will be explored and the parent of a child diagnosed by NBS will share her experience and thoughts.