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30th Annual North American Cystic Fibrosis Conference

S02: CFTR: Understanding Missense & Misfolding Mutations in CFTR

Oct 27, 2016 2:00pm ‐ Oct 27, 2016 3:25pm

Standard: $49.99


This symposium aims to provide insights into the mechanisms how the most common CF mutations, categorized by the CFTR2 initiative, influence CFTR structure and function. This will be discussed in light of the CFTR 3D model, with a particular focus on structures of the nucleotide-binding domains (NBDs). Furthermore, this session will also discuss how the cellular proteome may deferentially process CF mutations.

Educational Objectives:
  • Describe the latest data on categorizing the CFTR2 database concerning trafficking, function and clinical manifestations.
  • Explain how CF mutations influence CFTR structure and function using 3D models of CFTR and structures of the NBDs.
  • Identify how mutation-specific interactome directs the fate of CFTR.


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