Several recent advances in the pathogenesis of CF lung infections will be presented. The contribution of inflammasomes to excess inflammation and worsening of lung function in CF will be discussed, as will evidence that the IL-1R antagonist anakinra blocks these detrimental effects. The results of studies applying isotope ratio mass spectrometry to sputum to quantify the growth rate of Staphylococcus aureus within the lungs of CF patients will be described. The importance of CF animal models in understanding CF lung infections will be reviewed. Finally, evidence will be presented to support the use of powerful omic techniques in the care of CF patients. These developments illustrate how a better understanding of host:pathogen interactions can inform translational approaches for CF.
Evaluate state-of-the-art techniques used to characterize host:pathogen interactions within the CF lung.
Describe host defense mechanisms and defects relevant to infections of the CF lung.
Discuss how recent developments in the understanding of host:pathogen interactions in CF airways are being applied to translational strategies.