The airway epithelium is covered by an aqueous film termed the airway surface liquid (ASL) and its composition is tightly regulated through ion and fluid movements. One of the hallmarks of the lung pathophysiology in CF is the presence of a thick, sticky, mucus that provides a favorable environment for bacterial growth. Understanding how we can modify the composition of the ASL and reduce mucus viscosity is of major importance if we want to identify new therapeutic targets that can improve the quality of airway secretions by rehydrating mucus. This session will focus on the importance of regulating ion transport, mucus and ASL composition.
Describe two ways of regulating CFTR.
Report on different methods to analyse mucus.
Discuss the importance of surface pH in the airways.