This workshop will provide attendees an overview of research submitted as abstracts pertaining to pathogenesis of infection in CF. Topics relate to the intersection of microbial virulence and the host immune response that modulates the disease process. Approaches utilize a spectrum of in vitro, in vivo, animal models and clinical/human subjects strategies.
Describe pathogenic mechanisms employed by bacteria and viruses to circumvent or exploit host defense mechanisms in the CF airway.
Discuss the challenges of antimicrobial therapeutics in CF and new strategies to circumvent these.
Describe how CFTR defects impact innate immunity and inflammation in response to respiratory pathogens