This workshop contains presentations of research submitted as abstracts pertaining to Adult and Pediatric Endocrinology in CF (including diabetes & bone). Topics this year related to bone disease include direct assessments of bone quality in human bone samples, the effect of CFTR correctors on CF osteoblasts and bone disease in the CF rat model. Topics pertinent to diabetes include a report of early glucose abnormalities in infants and children with CF, the role of advanced glycation end products in CFRD, prediction of CFRD using a genetic modifier of CFRD in conjunction with lab testing during the first years of life and the effect of CFRD on survival of UNOS registrants.
Summarize summarize newly appreciated glucose abnormalities and their clinical consequences in people with CF
Relate relate non-invasive and invasive measurements of bone quality to risk of fracture in people with CF
Describe describe how gene expression in osteoblasts differs between normal, CF, and CF in the presence of a CFTR corrector compound.
Associate Clinical Professor,
University of Iowa Stead Family Children`s Hospital