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28th Annual North American Cystic Fibrosis Conference

W21: CFTR: Intersection Between CFTR & Cellular Signaling

Oct 11, 2014 2:30pm ‐ Oct 11, 2014 4:15pm

Standard: $49.99


Many signaling molecules and pathways affect CFTR expression and/or function, thus directly impacting CFTR deficiency in CF. Conversely, lack of CFTR in CF cells and tissues alters cell functions other than anion conductance, such as inflammatory responses, that contribute to health outcomes. This session is devoted to presentations that highlight interplays between CFTR and its cellular environment that affect disease progression and/or the efficacy of therapeutic approaches for CF.

Learning Objectives:
  • Describe new pathways and signaling molecules (e.g. tyrosine kinases, TGFbeta1, ERK1/2) that regulate CFTR expression and/or function.
  • Identify signaling molecules and pathways that are altered/affected by lack of CFTR in CF cells and tissues (e.g. TLR4, TPPP and SLC26A9).
  • Summarize possible ways that manipulation of cell signaling can translate into improved therapies for cystic fibrosis.


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