The recently solved structures of full-length CFTR provide a template on which to evaluate electrophysiological and biochemical studies of this channel forming membrane protein. This symposium will discuss the cryo-electron microscopy structures of CFTR and their use for the interpretation of channel function studies and disease-causing mutations. Additionally, the symposium will explore the application of these structures for the development of new therapeutics for common and rare CF-causing alleles.
Examine the current structural and functional data to explore CFTR channel function.
Apply the existing structural and functional data to understand the molecular defects caused by CF-associated mutations.
Assess how structural and functional studies can be leveraged for future therapeutic development.