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31st Annual North American Cystic Fibrosis Conference

S01 - S01: CFTR: Orbiting the Atomic Structure

Nov 2, 2017 2:00pm ‐ Nov 2, 2017 3:25pm


The recently solved structures of full-length CFTR provide a template on which to evaluate electrophysiological and biochemical studies of this channel forming membrane protein. This symposium will discuss the cryo-electron microscopy structures of CFTR and their use for the interpretation of channel function studies and disease-causing mutations. Additionally, the symposium will explore the application of these structures for the development of new therapeutics for common and rare CF-causing alleles.

Learning Objectives:

  1. Examine the current structural and functional data to explore CFTR channel function.
  2. Apply the existing structural and functional data to understand the molecular defects caused by CF-associated mutations.
  3. Assess how structural and functional studies can be leveraged for future therapeutic development.

Symposium Chair(s):

Symposium Speaker(s):

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