This symposium aims to provide insights into the abnormal properties of CF mucus and explore different therapeutic approaches for CF lung disease. New data from recent clinical studies offer unique perspectives on the pathological changes in CF mucus related to hydration, pH and viscoelasticity. This symposium will focus on basic findings and recent efforts towards translating these advances into novel therapies.
Identify the basic defects of CF mucus responsible for impaired mucociliary clearance.
Discuss the different therapeutic approaches that address mucus clearance defects in CF.
Evaluate drug efficacy and tolerability tested in experimental models and in CF patients.