Ion and fluid transport mediated by CFTR does not happen in isolation; it happens as a multi-protein complex on the plasma membrane. CFTR is activated by its phosphorylation by various kinases (e.g., cAMP-/cGMP-activated protein kinases), by interacting with these kinases. It has been demonstrated that other proteins also regulate CFTR activity such as other ion channels, transporters, and scaffolding proteins. Since very little is known about the CFTR-interacting partners and the role they play in coupling CFTR to other regulatory or ion-conducting proteins in CFTR's neighborhood, the theme of this symposium will be 'CFTR's Neighborhood: It's All About Location'.
Define how CFTR and its interacting partners behave in microdomains of the plasma membrane.
Define how CFTR is regulated by secondary messengers at or near the plasma membrane.
Define how airway pH is regulated by CFTR interacting partner ATP12A and how SLC26A9 function is regulated by the mutant CFTR protein.