Cystic Fibrosis disease presentation and progression vary widely across people living with CF, with CFTR mutations only partially accounting for overall phenotype. This workshop session will provide an update on international studies of genetic and environmental modifiers of CF lung disease. New approaches for discovering genetic modifiers, and novel targets for modification of CF lung disease will be discussed.
Describe genes and environmental mechanisms thought to be important to CF lung disease.
Relate non-CFTR genetic modifiers to the pathogenesis of CF lung disease and additional pulmonary diseases.
Compare and contrast research strategies used to discover novel modifier genes with techniques used to study underlying mechanisms of identified modifier genes.