As CF lungs at birth shows few signs of infection and inflammation, an emerging concept is that external challenges may precipitate the onset of infection and inflammation that persist into chronic lung disease. External challenges such as microaspiration of commensal upper airway bacteria or respiratory virus infections are potential external challenges that young CF lungs may not resolve as effectively as young non-CF lungs. This Symposium reviews the current knowledge of the status of the young CF lung and what the early challenges to the maintenance of airway health may be. By identifying external triggers of CF airway disease, strategies can be developed to minimize the risk of compromising the young CF. Learning Objectives:
Summarize the evolution of lung disease in the CF lung with age.
Appraise the changing microbiota as it evolves in the CF lung over time.
Evaluate the relative contribution of microaspiration versus respiratory virus infection.
Note: Speaker Stephen Stick's presentation was not recorded at his request.