Recent research has identified that both normal and mutant CFTR function can be modulated by endogenous and exogenous elements. This session will describe several studies focusing on how to understand current CFTR modulator compound interactions with CFTR as well as endogenous cellular mechanisms that regulate CFTR trafficking and function.
Summarize the mechanism of action of existing small molecule therapies on CFTR and how they physically interact with CFTR.
Summarize how post-translation modification of CFTR (e.g., sumoylation) can significantly regulate CFTR maturation or degradation.
Describe how other endogenous proteins may alter CFTR trafficking and function through direct interactions.
Note: Speakers Christine Bear and Jue Chen's presentations were not recorded at their request.