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32nd Annual North American Cystic Fibrosis Conference


S10--CFTR: Say Hello to CFTRs Little Friends


Oct 19, 2018 10:30am ‐ Oct 19, 2018 11:55am

Description

Recent research has identified that both normal and mutant CFTR function can be modulated by endogenous and exogenous elements. This session will describe several studies focusing on how to understand current CFTR modulator compound interactions with CFTR as well as endogenous cellular mechanisms that regulate CFTR trafficking and function.

Learning Objectives:

  • Summarize the mechanism of action of existing small molecule therapies on CFTR and how they physically interact with CFTR.
  • Summarize how post-translation modification of CFTR (e.g., sumoylation) can significantly regulate CFTR maturation or degradation.
  • Describe how other endogenous proteins may alter CFTR trafficking and function through direct interactions.

Note: Speakers Christine Bear and Jue Chen's presentations were not recorded at their request. 

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Symposium Speaker(s):

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