This session focuses on the mechanism by which CF-related pathogens establish infection and persist in the host. The session will start with Staphylococcus aureus as one of the earliest and most prevalent microorganism in CF, which can persist in the airways for years or even decades. The second talk will focus on the fitness traits exhibited by Pseudomonas aeruginosa colony variants and the selective forces that underlie conversion and patho-adaptation during chronic infection. This will be followed by a talk describing how Burkholderia cenocepacia senses the amino acid-rich environment of the cystic fibrosis lung and elicits an adaptive response that is niche-specific according to nutritional differences. The final talk will describe microbiome methods and how they differ and limitations of each. This session will offer new advances in microbial pathogenesis and how the microbiome alters lung disease pathogenesis in CF.
Describe microbial adaptation for Staphylococcus aureus, Pseudomonas aeruginosa and Burkholderia cenocepacia in CF.
Evaluate the microbiome approaches and how the study of microbiome in CF changed the way we think about pathogenesis in CF.
Characterize the most recent updates in the field of microbial pathogenesis in CF.