Jonathan Fay Ph.D.

University of North Carolina at Chapel Hill

Jonathan Fay is a postdoctoral fellow at the University of North Carolina at Chapel Hill in Dr. Riordan's Lab. His research and scientific interest are focused on membrane proteins, at the intersect of pharmacology, biochemistry and biophysics. Previously he had worked on an intractable high priority GPCR target. Which he purified in a functional form and explored GPCR receptor structure and function using classical pharmacological approaches, membrane protein biochemistry, and innovative fluorescence assays aimed at understanding the mechanisms through which structural rearrangements occur upon a receptor binding to both orthosteric and allosteric drugs. His more recent work has been exploring membrane protein structure using single particle electron microscopy (EM). Specifically, his efforts have focused on ATP binding cassette subfamily C (ABCC), leading to a publication of the cryoEM structure of KATP. He now works with the Riordan Lab to continue his efforts of using EM for membrane protein structure determination of another ABCC family member, CFTR.