Zhe Zhang Ph.D.

The Rockefeller University

Zhe received a B.S. in Biotechnology from Shandong University, China in 2008. In 2015, he received a Ph.D. degree in Biochemistry and Molecular Biology from the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. His Ph.D. studies focused on the endocytosis process, specifically structural and functional studies of the Rab GTPases in complex with their GEF and effector proteins. He showed the molecular mechanism for the regulation of the Rabex-5 GEF activity and the binding specificity of Rab9A with RUTBC2. He joined Jue Chen's lab as a postdoctoral associate of the Rockefeller University in 2015 and started to work on the structure of CFTR (cystic fibrosis transmembrane conductance regulator). He solved the 3.73 Ã… cryo-EM structure of zebrafish CFTR and 3.87 Ã… structure of human CFTR in the closed conformation, these are the first structures of CFTR at nearly atomic resolution. Currently he is pursuing the structures of both zebrafish and human CFTR in other functional states, as well as the mechanical characterization of the channel gating cycle and the mode of action for a couple related drugs.