Hannah Swahn BS.c.

Case Western Reserve University

Hannah Swahn eRA Commons Username: hswahn Position Title: Ph.D. Student, Department of Genetics and Genome Sciences Education B.S. in Biology (Denison University, Completed 05/2016) Ph.D. in Genetics and Genome Sciences (Case Western Reserve University, In Progress) Professional Memberships 2016 - Present Member, Sigma Xi Honors 2012 - 2016 Founders Scholarship, Denison University 2015 Co-Curricular Learning Certificate, Arcadia University Contributions to Science My undergraduate work bridged molecular genetics and neurobiology, as it focused on potential dosage sensitive interactions between genes involved in the arborization of the larval body wall of Drosophila melanogaster, and how these interactions might impact class IV dendritic arborization (da) neuron morphology and forager-to-wanderer transition in third instar larva. Although this study did not reveal any dosage-sensitive interactions between the genes of interest, it did elucidate the importance of class IV da neuron morphology in promoting proper forager-to-wanderer transition as an over-branching phenotype correlated with an impairment of the transition. Furthermore, this study revealed that failure to undergo forager-to-wanderer transition is separable from mechanical nociception responses, which was surprising as both forager-to-wanderer transition and mechanical nociception responses are reliant on class IV da neurons. All authors listed (*) contributed equally to the publication. Brown, H.E.*, Desai, T.*, Murphy, A.J.*, Pancholi, H.*, Schmidt, Z.W.*, Swahn, H.* & Liebl, E.C. (2017) Dendritic branching of Drosophila larval class IV dendritic arborization sensory neurons correlates with the ability to undergo forager-to-wanderer transition, but not with mechanical nociception responses. In review. Ongoing Research Support 4T32 GM008056-34 Coller (PI) 05/01/2017 - Present Regulatory Role of Chromosome 11p13 in Cystic Fibrosis Lung Disease Severity The goal of this study is to elucidate the regulatory mechanisms by which the modifier region at 11p13 contributes to CF lung disease severity. More specifically, the goal of this study is to determine how potentially important cis-elements within the region work. Completed Research Support Gilpatrick Center Senior Research Grant, Denison University Liebl (PI) 11/2015 - 05/2016 Investigating Dosage Sensitive Interactions Between trio, trc and fry in Drosophila melanogaster The goal of this study was to reveal any potential dosage sensitive interactions between trio, tricornered (trc) and furry (fry) in Drosophila melanogaster, and uncover how these interactions might impact class IV dendritic arborization (da) neuron morphology and forager-to-wanderer transition in third instar larva.

Appearances