Pavana Gururaj Rotti B.E., M.S.

Graduate Student Assistant, University of Iowa

NAME: Pavana Gururaj Rotti POSITION TITLE: PhD Student EDUCATION/TRAINING RV College of Engineering, KA, India BE 06/2011 Biotechnology The University of Iowa, IA, USA MS 12/2014 Biomedical Engineering The University of Iowa, IA, USA PhD ongoing Biomedical Engineering A. Personal Statement I am a PhD student in Dr. John Engelhardt's lab in the Department of Antomy and Cell Biology at University of Iowa. I work on unraveling the pancreatic endocrine and exocrine axis. My undergraduate degree was in Engineering with Biotechnology as my major. Soon after graduating, I worked in a fundamental research institute called National Center for Biological Sciences. Here, I received extensive training in microscopic techniques like confocal and multi-photon microscopy, which I currently use in my research. For my Masters, I joined the Biomedical Engineering program at the University of Iowa and worked on a thesis titled "3D culture enhances differentiation of induced pluripotent stem cells to insulin producing cells". I got my first co-author publication during my masters and got opportunities to present various aspects of the project at multiple reputed conferences (see below). I joined Dr. John Engelhardt's lab for my PhD and have had multiple successful collaborations that work towards my thesis. My work is primarily on the Cystic Fibrosis induced pathology in the pancreas and its effect on signaling between different cell types in the pancreas. My previous training in engineering and ongoing training in basic sciences gives me a unique niche and perspective to questions in basic sciences. B. Positions and Honors 2011-2012 Junior Research Fellow, National Center for Biological Sciences, TIRF, Bangalore, India 2012-2014 Graduate Student Researcher, Department of Biomedical Engineering, University of Iowa, USA 2015-present Graduate Student researcher, Department of Anatomy and Cell Biology, University of Iowa, USA C. Contributions to Science 1. Hao, Z., et al. (2017). Real-time monitoring of insulin using a graphene aptameric nanosensor. Micro Electro Mechanical Systems (MEMS), 2017 IEEE 30th International Conference on, IEEE 2. Rotti, P., et al. (2016). ROLE OF BRADYKININ AND CGRP IN PANCREATIC ENDOCRINE DYSREGULATION IN CYSTIC FIBROSIS. PEDIATRIC PULMONOLOGY, WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA 3. Manzar, G. S., et al. (2015). Generation of Glucose-Responsive Pancreatic beta-Cells from Type 1 Diabetic Patient Human iPS Cells In Vitro. Diabetes, AMER DIABETES ASSOC 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA 4. Hao, Z., et al. (2017). 'Real-Time Monitoring of Insulin Using a Graphene Field-Effect Transistor Aptameric Nanosensor.' ACS Applied Materials & Interfaces 5. Manzar, G., et al. (2015). Human iPS Cell-Derived Pancreatic beta-Cells Correct Hyperglycemia in Diabetic Mice. AMERICAN JOURNAL OF TRANSPLANTATION, WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA 6. Manzar, G., et al. (2014). Human ips Cell-derived Insulin Producing Cells Form Organoidsin Vivothat Are Glucose Responsive in Diabetic Mice. American Journal of Transplantation 14: 48 7. Manzar, G. S., et al. (2014). 'Skin deep: from dermal fibroblasts to pancreatic beta cells.' Immunologic research 59(1-3): 279-286 D. Additional Information: Research Support and/or Scholastic Performance 1. Nominated Student member of AAAS 2. Semi-finalist for Junior Investigator Award in NACFC 2017