Sly, Peter David Personal Statement I have extensive experience in CF in both clinical care and research. I have been a consultant respiratory specialist for over 25 years. While my primary training was in respiratory physiology, I have an established track record investigating infection and inflammation, and the underlying mechanisms of airway disease, particularly in CF. In 1999 I was one of the key persons in establishing the AREST CF early surveillance program. Through this program I have published data leading to the understanding of links between inflammation and infection, and infection/inflammation and lung function and structural lung disease. I have also contributed to consensus statements in the area of cystic fibrosis. B. Positions and Honors Positions 1985-87 Post-Doctoral Research Fellow, Meakins Christie Labs, McGill University, Montreal, Canada 1987-90 Thoracic Physician, Royal Children's Hospital, Melbourne, Australia 1991-09 Head, Division of Clinical Sciences, Telethon Institute for Child Health Research, Perth, Aust 1991-09 Respiratory Physician, Princess Margaret Hospital for Children, Perth, Australia 2000-09 Professor, Centre for Child Health Research, University of Western Australia 1999-06 Director, Research and Education, Princess Margaret Hospital for Children, Perth, Australia 2006-10 Director, WHO Collaborating Centre for Research on Children's Environmental Health 2010-16 Deputy Director, Queensland Children's Medical Research Institute, Brisbane, Australia 2010- Respiratory Physician, Royal Children's Hospital, Brisbane, Australia 2010- Professor, University of Queensland 2013- Director, WHO Collaborating Centre for Children's Health and the Environment Honors 1985 Post Doctoral Fellowship, Medical Research Council of Canada 1994 NH&MRC Senior Research Fellowship 1996 Australian Lung Foundation Ludwig A. Engel Grant-in-Aid for Physiological Research 1997 NH&MRC Principal Research Fellowship 2001 NH&MRC Senior Principal Research Fellowship (renewed 2006) 2005 Thoracic Society of Australia and New Zealand Research Medal 2005 The Dr. H. Paramesh Oration, Indian Academy of Pediatrics 2007 The Ann Woolcock Oration, Asian Pacific Society of Respirology 2008 Fellow, Collegium Ramazzini 2010 The Jerry Dolovich Memorial Lectureship, American Academy of Allergy, Asthma & Immunology 2013 Harasawa Award, Asian Pacific Society of Respirology 2014 Fellow, Thoracic Society of Australia and New Zealand 2014 Fellow, European Respiratory Society 2015 Fellow, Australian Academy of Health and Medical Sciences 2015 Fellow, Asian Pacific Society of Respirology 2015 Richard C Talamo Award for Distinguished Clinical Achievement, Cystic Fibrosis Foundation, USA. 2016 Officer, Order of Australia Professional Society Memberships 1987 American Thoracic Society 2000 European Respiratory Society 1996 National Association of Research Fellows (Aust.) 1985 Royal Australasian College of Physicians 1987 Thoracic Society of Australia and New Zealand Contribution to Science I am an acknowledged pioneer in understanding the early origins of lung disease and the implications for lung health in the long term. He has discovered major risk factors for the development of asthma and for the onset of cystic fibrosis lung disease, leading to a number of testable hypotheses to prevent or delay the onset of lung disease, which are currently being trialed internationally. He has been instrumental in developing methods for measuring lung function in infants which enable for the first time the study of antenatal versus postnatal environmental influences on lung growth and development.