Andrea Granados M.D.
I am a board certified pediatric endocrinologist at Washington University in St Louis, MO with clinical and academic interests in cystic fibrosis related diabetes (CFRD). I became intrigued by the pathophysiology, management and prognostic implications of CFRD early in my training. Under the mentorship of Dr. Ana Maria Arbelaez, my primary mentor, I have completed a research project in which primary goal was to determine if insulin resistance or Î²-cell insulin secretion, relate to clinical outcomes in 15 young, clinically stable patients with cystic fibrosis (CF). In this study we demonstrated a positive correlation between insulin resistance and higher weight z-scores and body fat composition. These findings suggest the need for further extensive studies to examine the relationship between body composition and glucose dysregulation and clinical outcomes in CF youth; this is the primary focus of my research. In addition, I am interested in evaluating the effects of physical activity on body composition, glucose dysregulation and CF clinical outcomes. I was selected to be one of 8 pediatric endocrinologists in the nation who are â€œEmerging Leadersâ€ in CF endocrinology, through the EnVision Program funded by the CF Foundation. This program provides formal interaction with senior leaders in the field, including extensive interaction with my mentor, Dr. Antoinette Moran, a world-renowned expert in type 1 diabetes and CFRD. In the past year, I have established a joint Endocrine/Pulmonology clinic with assistance of Dr. Thomas Ferkol, my secondary mentor for this project, and Director of the Division of the Pediatric Allergy, Immunology, and Pulmonary Medicine. Dr. Ferkol is an internationally recognized expert on airway-specific drug delivery and non-invasive measures of inflammation in the cystic fibrosis lung and is an outstanding collaborator and advisor. This joint Endocrine/Pulmonology clinic provides high quality and specialized care to the CF population and it has become a perfect environment to develop my clinical and research interests