Dean R. Madden Ph.D.

Geisel School of Medicine at Dartmouth

Dean Madden received his A.B. in Physics from Harvard College and began working in the area of biophysics during research internships in Berlin, Munich, and Tokyo. He returned to Harvard and received his Ph.D. in Don Wiley's laboratory, where he used crystallography to analyze the specificity of viral antigen presentation in peptide:MHC complexes. During a post-doctoral fellowship with Bert Sakmann, and then as an independent group leader at the Max Planck Institute for Medical Research in Heidelberg, Germany, he redirected his interests towards ion channels, focusing on ionotropic glutamate receptors and their functional domains. In 2001, he joined the faculty of the Geisel School of Medicine at Dartmouth, where he is currently Professor of Biochemistry and Associate Director of the Dartmouth Lung Biology Center. His current research interest include ion-channel conformational flexibility, trafficking, and localization. In the context of CF, his work focuses on the molecular interactions that regulate the half-life and overall amount of functional CFTR at the apical membrane of airway epithelial cells. The laboratory leverages this information to develop inhibitors of endogenous and bacterial protein targets, using peptide-array and high-throughput screening, as well as structural and mechanistic approaches.