Nicholas Keiser Ph.D.

Nicholas Keiser received his B.A. from Colgate University in 2000, and his Ph.D. from the University of Pennsylvania in 2006. His doctoral training was completed under the mentorship of Jean Bennett, and involved using viral vectors as tools to study genetic diseases of the retinal pigment epithelium. He performed post-doctoral research in the laboratory of John Engelhardt at the Unversity of Iowa, where he studied the intracellular trafficking of adeno-associated viral vectors, as well as mechanisms of innate immunity and inflammation in the CF ferret model. His work in the CF ferret lung uncovered numerous inflammatory changes at birth, in addition to defective antimicrobial killing. In 2014, he assumed a position as an Associate in the Department of Anatomy and Cell Biology at the University of Iowa. He is also an Associate Member of the University of Iowa Center for Gene Therapy for Cystic Fibrosis, where he holds a Pilot Grant to study early inflammation in the CF ferret lung. Under the mentorship of John Engelhardt, he currently pursues research into the pathophysiology of early CF lung disease, including the role of airway secretions, inflammatory pathways, and alveolar macrophages.