Frédéric Velard Ph.D.


I started my career by studying innate inflammatory processes in biomaterials-related bone disorders at Reims University, France. After I have defended my PhD I was post-doc fellow in Paris, France, where I worked on joint tissue degradation in osteoarthitis pathological context. Then I acceeded to my actual position as Research engineer in 'Biomaterials and inflammation in bone' laboratory where I mostly work on Cystic Fibrosis Related Bone Disease. My major area of interests concern human primary bone cells behavior. Last years I have focused on osteoblasts, which are the cells responsible bone formation, and how CFTR defective activity impacted their abilities to fully differentiate and create new bone. I was also involved in deciphering the impaired expression of molecules involved in cellular communication inside bone in Cystic Fibrosis. Now I am interested in osteoclasts, the cells that resorb the bone, and more especially their formation and activity in the Cystic Fibrosis context. I am also involved in studying the bone phenotype, at the organ level, in animal models like F508del mice and CFTR KO piglets.