Christoph Randak M.D.

Associate Professor

Dr. Christoph Randak graduated from Medical School at the University of W├╝rzburg, Germany, in 1992, and from the University of Hagen (FernUniversit├Ąt Hagen), Germany, with a Master-Diploma in Computer Science (Diplom-Informatiker) in 1996. After medical school he continued with a Pediatric residency at the Dr. von Haunersches Kinderspital of the University of Munich, Germany, followed by a fellowship in Neonatology at the same institution. He completed postdoctoral studies in CFTR electrophysiology with Dr. Michael Welsh at the University of Iowa from 2001-2007. From 2007-2009 he did a clinical fellowship in Pediatric Pulmonology at the Department of Pediatrics at the University of Iowa. He then joined the faculty as Assistant Professor of Pediatrics in the Pediatric Allergy-Pulmonary Division at Iowa and was promoted to Associate Professor with tenure in 2017. Since the early 1990s Dr. Randak's research focuses on CFTR, a regulated anion channel in the "adenosine 5'-triphosphate (ATP)-binding cassette" (ABC) transporter protein family. ABC transporters are ATPases, i.e., they hydrolyze ATP to adenosine 5'-diphosphate (ADP) and inorganic phosphate (Pi) (ATP + H2O -> ADP + Pi). This activity is coupled to substrate transport across biological membranes. Dr. Randak's main accomplishment and research focus is the demonstration that CFTR also has adenylate kinase activity (ATP + AMP <-> ADP + ADP), when ATP and adenosine 5'-monophosphate (AMP) both are present. Adenylate kinase activity has subsequently also been shown in other ABC proteins. Dr. Randak's current research focuses on the physiologic role of CFTR adenylate kinase activity and whether the active center can be targeted to treat cystic fibrosis or CFTR-dependent secretory diarrhea. He is currently funded through an NIH/NIDDK R01 award. He serves on the Editorial Board of the Journal of Biological Chemistry.