Amal Amer M.D., Ph.D.


Current position THE OHIO STATE UNIVERSITY, Columbus, Ohio, 2007-present Professor (Tenured) 2016-present Department of Microbial Infection and Immunity Manage a research laboratory, train graduate, undergraduate, and medical students, obtain federal and private funds, teach immunology and microbiology, and participate in committees. Prior positions Associate Professor, Department of Microbial Infection and Immunity, Ohio State University. 2012-2016 Assistant Professor, Department of Internal Medicine, Ohio State University. 2007-2012 Post-doctoral Fellow, University of Michigan, Cancer Center, Ann Arbor. 2004-2007 Post-doctoral Fellow, University of Michigan, Department of Microbiology and Immunology. 2001-2004 Doctoral Student, University of Western Ontario, Department of Microbiology and Immunology, London, Canada. Personal Statement With more than 15 years-experience in the field of innate immunity, I have been intensely engaged in studies to understand how the innate immune system recognizes and responds to pathogens and how mutations in these sensing systems affect the development of infectious and inflammatory diseases in humans. I have employed my expertise to better understand the pathobiology of human genetic diseases such as cystic fibrosis (CF). We have made important contributions to the field of CF, inflammasomes and autophagy field and ongoing studies are investigating the sophisticated system governing the activation of signaling cascades and the mechanisms involved. Our accomplishments include a number of publications in high impact journals such as Nature Scientific Reports 2015, Immunity 2012, Autophagy 2012, 2015, 2018 and Plos Pathogens 2009. As one of the most active groups in the autophagy field, host pathogen interaction and inflammasome, we have obtained and developed a large collection of tools and animal models to investigate signaling pathways affecting autophagy, caspases, the actin machinery, innate immunity and inflammation. I have employed these tools in the field of CF and was the first group to demonstrate that macrophages play an important role in the pathogenesis of CF. I was the first to demonstrate that autophagy is compromised in CF macrophages and that targeting autophagy is beneficial to CF patients. I have trained undergraduate, graduate students and postdoctoral and clinical fellows in CF research. All my trainees proceeded with positions in academia and industry with emphasis on CF. I am devoted to teaching and my remarkable teaching evaluations are a testament of my abilities. I have also helped students in primary schools to better understand CF and answer questions addressing their concerns. My seminars and my lectures always describe the pathobiology of CF and how it exemplifies innate immunity deficiency, dysfunctional autophagy and exacerbated inflammation. International Grant Advisory Committees: 2009 The Health research Board. Postdoctoral fellowships. Ireland. 2012 Reviewer for Fonds Wetenschappelijk Onderzoek Research Foundation FWO Flanders, Belgium. 2012 Reviewer for Cystic Fibrosis Foundation 'Fondazione per la Ricerca sulla Fibrosi Cistica', Italy. 2013 Reviewer for Cystic Fibrosis Foundation. United Kingdom. 2013 Reviewer for The Fulbright postdoctoral fellowships. 2014 Reviewer for The Medical research Council (MRC). United Kingdom. 2014 Reviewer for Fonds Wetenschappelijk Onderzoek Research Foundation FWO Flanders, Belgium. Federal Advisory Committees: Service on NIH Study Section. 2011 Ad-hoc Member, Study Section HIBP. Host Interaction with Bacterial Pathogens Study Section. 2012 Ad-hoc Member, Study Section LCMI. Lung Cellular, Molecular, and Immunobiology Study Section. 2013 Ad-hoc Member and Co-Chair, Special Emphasis Panel. 2013 Ad-hoc Member, Special Emphasis Panel. 2014 Ad-hoc Member, Study Section Topics in Bacterial pathogenesis and virulence IDM-V02 2014 Ad-hoc Member, Study Section LCMI Lung Cellular, Molecular, and Immunobiology. 2014 Ad-hoc Member, Study Section NHLBI K99 special emphasis. 2015 Ad-hoc Member, Study Section NIAID K99 special emphasis. 2015 Ad-hoc Member, Study Section III 2015 Ad-hoc Member, Study Section IHD 2015 Ad-hoc Member, Study Section ZRG1 DM 2014-2016 Permanent member, MTI (Mentored Transition to Independence; K99, K22) NHLBI Study Section. 2016 Ad-hoc Member, Study Section ZRG1-BCMB-A 51 2016-2020 Permanent member, Innate Immunity and Inflammation (III) Study Section Contribution to Science (out of 57 publications) 1. I have focused on the study of Autophagy for many years and I was among the early scientists who demonstrated that autophagy controls intracellular pathogens. Our report was published in the first issue of Autophagy in 2005. Then, recently I have characterized the role of autophagy in cystic fibrosis (CF) and how it predisposes CF patients to specific infections. My publications have been subject of press releases and established new paradigm in the pathology of CF. a. Kathrin Krause, Kyle Caution, Asmaa Badr, Kaitlin Hamilton, Abdulmuti Saleh, Khushbu Patel, Rana Hegazi and Amal O. Amer. 2018. Caspase-11 promotes autophagosome formation in response to starvation and bacterial infection. Autophagy Journal. Accepted b. Kathrin Krause, Benjamin T. Kopp, Mia F. Tazi, Kyle Caution, Kaitlin Hamilton, Asmaa Badr, Chandra Shrestha, Dmitry Tumin, Don Hayes, Frank Robledo, Luanne Hall-Stoodley, Brett G. Klamer, Xiaoli Zhang, Santiago Partida-Sanchez, Narasimham L. Parinandi, Stephen E. Kirkby, Duaa Dakhlallah, Karen S. McCoy, Estelle Cormet-Boyaka and Amal O. Amer. 2017. The expression of Mirc1/Mir17-92 cluster in sputum samples correlates with pulmonary exacerbations in cystic fibrosis patients. Journal of cystic fibrosis. S1569-1993(17)30962-1. PMID: 29241629 c. Mia F. Tazi, Duaa A. Dakhlallah, Kyle Caution, , Amr Ahmed, Hany Khalil, Ian Davis, Clay Marsh, Larry S. Schlesinger, Estelle Cormet-Boyaka and Amal O. Amer. 2016. Elevated miR-17~92 cluster expression negatively regulates autophagy and cystic fibrosis transmembrane conductance regulator (CFTR) function in CF macrophages. Autophagy Journal. 12(11):2026-2037. PMID: 27541364. d. Abdulrahman BA, Khweek AA, Akhter A, Caution K, Kotrange S, Abdelaziz DH, Newland C, Rosales-Reyes R, Kopp B, McCoy K, Montione R, Schlesinger LS, Gavrilin MA, Wewers MD, Valvano MA, Amer AO. 2011. Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis. Autophagy. PMCID:3359483 7: 1359-70 e. Kyle Caution, Mikhail A. Gavrilin, Mia Tazi, K. Apurva, Daniel Layman, Sheshadri Hoque, Kathrin Krause and Amal O. Amer. 2015. Caspase-11 and caspase-1 differentially modulate actin polymerization via RhoA and Slingshot proteins to promote bacterial clearance. Nature Scientific reports. 5:18479. f. Akhter A, Caution K, Abu Khweek A, Tazi M, Abdulrahman BA, Abdelaziz DH, Voss OH, Doseff AI, Hassan H, Azad AK, Schlesinger LS, Wewers MD, Gavrilin MA, Amer AO. 2012. Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization. Immunity. PMCID:3408798 37: 35-47 g. Gavrilin MA, Abdelaziz DH, Mostafa M, Abdulrahman BA, Grandhi J, Akhter A, Abu Khweek A, Aubert DF, Valvano MA, Wewers MD, Amer AO. 2012. Activation of the Pyrin Inflammasome by Intracellular Burkholderia cenocepacia. J Immunol. PMCID:3482472 188: 3469-77 h. Akhter A, Gavrilin MA, Frantz L, Washington S, Ditty C, Limoli D, Day C, Sarkar A, Newland C, Butchar J, Marsh CB, Wewers MD, Tridandapani S, Kanneganti TD, Amer AO. 2009. Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection. PLoS Pathog. PMCID: 2657210 5: e1000361 Complete List of Published Work in MyBibliography (54): h-index 33, i10-index 47, citations 11,815 https://urldefense.proofpoint.... Ongoing Research Support - R01 (1R01AI124121-01) (MPI: Amer/Cormet-Boyaka) Restoring macrophage function in cystic fibrosis 2016-2021 - R01 1R01HL127651-01A1 (MPI: Amer) The role of microRNA-calibrated autophagy in innate immunity and inflammation 2015-2019