Jack Wellmerling M.S.
My first exposure to research was as an intern following my undergraduate training in the lab of Dr. Gunjan Agarwal at OSU starting in the summer of 2014. This experience prompted me to join the Biophysics Graduate Program at OSU in the summer of 2015, where I was exposed to a broad array of topics in biophysics through comprehensive coursework and research rotations. I found the topics of ion channel physiology and cellular signal transduction to be especially interesting. This led me to join the laboratory of Dr. Estelle Cormet-Boyaka in February of 2016, where I have contributed to several projects involving the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and its role in inflammatory airway diseases such as Chronic Obstructive Pulmonary Disease (COPD) and Cystic Fibrosis (CF). During my training, I have become adept at measuring ion channel function with Ussing chambers and have collected valuable data for our lab and others. In addition, I am well-equipped to culture primary human airway epithelial cells through collaboration with the Cure CF Columbus Epithelial Cell Core. I have been trained in molecular methods to study cellular signaling events related to regulation of the CFTR ion channel. Finally, our lab has the capability to measure several biophysical indicators of mucociliary clearance, including ciliary beat frequency and airway surface liquid height. I believe this skillset provides me with a strong foundation to conduct the proposed research.