Ana Crane Ph.D.

Research Scientist, Centre for Stem Cell Research and Regenerative Medicine

Dr. Ana M. Crane received a B.S. in Biochemistry and Clinical Analysis in 1976 from the University of Buenos Aires, Argentina. She later went on to receive a Ph.D. in Molecular Biology in 1994 from the University of Buenos Aires, Argentina. Her industry training began in 1995 at Gene Medicine, Inc., in Houston, Texas, where she assumed the role of Senior Scientist researching non-viral gene therapy for cancer until 1997. She then worked as a Research Associate at Baylor College of Medicine in Houston, Texas, from 1997 to 2007, and later assumed the role of Instructor and Director of the hES Cell Culture Core until 2009. Presently she is a Research Scientist in the laboratory of Dr. Brian R. Davis, Center for Stem Cell and Regenerative Medicine, at the University of Texas Health Science Center at Houston. Her main research interests are gene correction for lung diseases such as cystic fibrosis (the CFTR gene) in patient-specific iPS cell lines using Zinc Finger Nucleases (ZFN), TALENs and Crispr/Cas9 nucleases to facilitate homology direct repair.Publications:1. *Fujita J, *Crane AM, Souza MK, Dejosez M, Kyba M, Flavell RA, Thomson JA, Zwaka TP. Caspase activity mediates the differentiation of embryonic stem cells. Cell Stem Cell. 2008 Jun 5;2(6):595-601. (* first authors)2. J. BryanJ , Crane A, Vila-Carriles WH, Babenko AP Aguilar-Bryan L. Insulin secretagogues, sulfonylurea receptors and K(ATP) channels . Curr Pharm Des. 2005;11(21):2699-716.3. Tornovsky S, Crane A, Cosgrove KE, Hussain K, Lavie J, Heyman M, Nesher Y, Kuchinski N, Ben-Shushan E, Shatz O, Nahari E, Potikha T, Zangen D, Tenenbaum-Rakover Y, de Vries L, Argente J, Gracia R, Landau H, Eliakim A, Lindley K, Dunne MJ, Aguilar-Bryan L, Glaser B. Hyperinsul