Shuyu Hao Ph.D.

Postdoctoral reseacher

Shuyu Hao received her Ph.D. from Case Western Reserve University in Genetics and Genome Sciences in 2019 in the lab of Mitchell Drumm, where she continues her post-doctoral training. Her research focuses on mechanisms underlying altered transcriptional regulation in CF cells. She is dissecting the roles of CFTR function from those of the intestinal environment in which the cells reside to parse how each contributes to CF intestinal disease, with emphasis on intestinal inflammation. She has been interested in understanding if/how CFTR's absence influences transcriptional regulation in CF intestinal epithelial cells and tissues. She is also studying how the CF intestinal environment contributes to the transcriptome of intestinal epithelial cells. She recently published an article in the Journal of Cystic Fibrosis describing the development of cell lines in which the CFTR gene was inactivated by CRISPR/Cas9 system and how the absence of CFTR affects inflammatory gene expression and mRNA regulatory networks in these cells. She is currently using murine intestinal crypts and organoids to further study the roles of CFTR and the complex intestinal environment in modulating the transcriptome of intestinal epithelium.