I have an extensive background in lung biology and pathophysiology starting from my graduate training Johns Hopkins, which focused primarily on inflammation and airway pharmacology in the laboratory of Dr. Allison Fryer. This was followed by training in lung cell and molecular biology with Dr. Burton Dickey at the Baylor College of Medicine where my focus shifted to the study of airway mucin production and secretion. I developed a further interest in basic mechanisms of lung inflammation and injury with a special focus on the function and regulation of the polymeric mucin glycoproteins Muc5ac and Muc5b. To study these two mucins, I developed knockout mice for each, as well as tools for assessing inflammatory phenotypes, particle clearance, and pathogen infection. In 2011, I relocated to the University of Colorado (CU) where we have further developed genetic and biochemical models to study the importance and mechanisms of Muc5ac and Muc5b functions. At CU, I hold a primary appointment in Pulmonary Medicine with a secondary appointment in Immunology. I am a training faculty member in Immunology, Integrated Physiology, the Masters in Integrated Sciences, and the Medical Scientist Training (MD/PhD) programs, and I am a mentor on R38, T32, F32, K01, and K08 training grants. I have served the CF Foundation in numerous roles and am also the current Co-chair of a mucociliary biology Gordon Conference. For my presentation for the 2018 NACFC, I will share our progress in better understanding how mucin isoforms serve specific functions in mouse lungs. Data will highlight how we use genetic models to understand how expression, polymerization, and glycosylation drive mucin isoform specific functions in the lungs. Results will highlight the importance of obstructive, transport, and clearance in CF-related disease models.