Paul Quinton PhD

NAME Quinton, Paul M. POSITION TITLE Professor, Pediatrics, UC San Diego Professor, Biomedical Sciences, UC Riverside INSTITUTION AND LOCATION DEGREE (if applicable) YEAR(s) FIELD OF STUDY University of Texas, Austin, TX B.A. 1967 English/Math Rice University, Houston, TX UCLA School of Medicine, L.A., Ca. Ph.D. Post Graduate 1971 1973 Cell Biology Cell Physiology A. Personal Statement Using the microperfused human sweat duct we discovered Cl- anion impermeability as the basic functional defect in the genetic disease, Cystic Fibrosis (CF). We followed this work with numerous studies of sweat glands and CFTR function, demonstrating roles for cAMP, ATP, kinase, phosphatase, intracellular pH and K+ concentration effects on ion conductance. We have been particularly concerned with the role of the defect in HCO3- secretion in CF. Accordingly, we extended this initial work on sweat glands to the more pathologically important targets of CF disease, namely small airways, intestine, and reproductive tissues. We have introduced a new basic concept to unite the generalized CF defect in mucus properties with its basic defect in ion transport that seems to largely explain the organ pathophysiology in CF; that is, mucin gel formation is surprisingly dependent on CFTR HCO3- secretion, but which is characteristically defective in CF tissues. Most recently our work in airways provided the first description and explanation of the role of the histological structure to the critical fluid transport functions of small airway in pulmonary hygiene. Relevant to the recent discovery of small solute pharmaceuticals for CF causing mutations, we developed two novel diagnostic biomarkers for sweat functions in CF that reflect defective CFTR channel function in both Cl- absorption and Cl- secretion. B. Positions and Honors Professional Experience 1973-1975 Assistant Research Physiologist Department of Physiology, UCLA Medical School 1975-1979 Assistant Professor (In Residence) Departments of Physiology and Medicine, UCLA Medical School 1978-1979 Assistant Professor (Visiting) Department of Physiology, Harvard Medical School 1979-1981 Assistant Professor of Biomedical Sciences Division of Biomedical Sciences, University of California, Riverside 1981-1984 Associate Professor of Biomedical Sciences Division of Biomedical Sciences, University of California, Riverside, and Associate Professor of Physiology Physiology of University of California, Los Angeles 1984-1990 Professor of Physiology University of California, Los Angeles 1984- Professor of Biomedical Sciences Division of Biomedical Sciences, University of California, Riverside 1997-2007 Adjunct Professor of Pediatrics Department of Pediatrics, University of California, San Diego 1998- Nancy Olmsted Chair in Pediatric Pulmonary Medicine University of California, San Diego 2007- Professor of Pediatrics Department of Pediatrics, University of California, San Diego Honors 1977 'Most Creative Lecturer'. UCLA Dental Class of 1977. 1983 Resolution of Appreciation, Cystic Fibrosis Research, Inc. 1986 Holsclaw Lecturer in Genetics, University of Arizona, Tucson. 1987 The Doris F. Tulcin Cystic Fibrosis Research Award. 1989 Investigator 'ad honorem', National Institute of Medical Genetics of Argentina. 1991 The Paul di Sant'Agnese Distinguished Scientific Achievement Award, National Cystic Fibrosis Foundation. 1994 Second Joseph Levy Memorial Lecture, International Cystic Fibrosis Foundation, Paris 2000 Inducted Fellow of the American Association for the Advancement of Science 2000 “Outstanding Contributions Award” Citizens University Committee, University of California, Riverside 2001 “Certificate of Recognition Award”, California State Assembly 2003 “Health Hero of the Year Award”, Combined Health Agencies of San Diego County 2007 “The 2007 Professional of the Year”, CFRI, Mountain view, Ca. 2009 “Heroes of Hope” Genentec Corp., November 2010 “Hans H. Ussing Lecture Award”, Epithelial Transport Group, American Physiological Society 2011 Rady Children’s Hospital Research Award 2015 “Distinguished Achievement Award”, American Thoracic Society


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